Cavidine protects against asthma in neonatal asthmatic mice model by attenuating PI3Ks/NF-κB signaling pathway

Purpose: To evaluate the protective effect of cavidine against asthma in neonatal mice.
 Methods: Neonatal mice were treated with at doses 5 and 10 mg/kg, po, 2 h prior to induction ovalbumin (OVA) on 1st 14th days treatment protocol. The anti-asthma activity was evaluated by determining number inflammatory cells cytokine levels broncho-alveolar lavage fluid (BALF) OVA-specific IgE TGF-β 1 serum OVAsensitized mice. NF-ƙB PI3K protein expression determined lung tissues OVA-sensitized Results: Cavidine attenuated cytokines BALF decreased significantly cavidine-treated groups, when compared asthmatic group mice, while downregulated (p < 0.01). altered signaling cavidinetreated sensitized OVA.
 Conclusion: These results reveal that OVA-induced occurs via reduction inflammation immune responsive linked PI3Ks/ NF-κB pathway tissues. findings suggest may be clinically suitable for management asthma.